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Development of oncolytic virotherapy: from genetic modification to combination therapy

Qiaoshuai Lan, Shuai Xia, Qian Wang, Wei Xu, Haiyan Huang, Shibo Jiang, Lu Lu

Frontiers of Medicine 2020, Volume 14, Issue 2,   Pages 160-184 doi: 10.1007/s11684-020-0750-4

Abstract: In this work, we review the use of wild-type viruses in OVT and the strategies for OV genetic modification

Keywords： immunotherapy     oncolytic virus     genetic modification     immune checkpoint blockade     chimeric antigen receptor    

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Developments in genetic modification of cattle and implications for regulation, safety and traceability

Jan Pieter VAN DER BERG, Gijs A. KLETER, Evy BATTAGLIA, Martien A. M. GROENEN, Esther J. KOK

Frontiers of Agricultural Science and Engineering 2020, Volume 7, Issue 2,   Pages 136-147 doi: 10.15302/J-FASE-2019306

Abstract:

Genetic modification techniques, in particular novel gene editing technologies, hold the yet unfulfilledpromise of altering genetic traits in farm animals more efficiently than by crossbreeding, allowing

Keywords： cattle     food safety     gene editing     genetic modification     GMO detection     regulation    

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Plant genetic engineering and genetically modified crop breeding: history and current status

Xingchun WANG,Shujun CHANG,Jie LU,Rupert FRAY,Don GRIERSON,Yuanhuai HAN

Frontiers of Agricultural Science and Engineering 2017, Volume 4, Issue 1,   Pages 5-27 doi: 10.15302/J-FASE-2017131

Abstract: This review charts the major developments in the genetic manipulation of plant cells that have takenThe toolkit available for genetic modification has expanded greatly since 1996 and recently Nobel Laureates

Keywords： plant transformation     transgene     genetic modification    

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The genetic regulation of skeletal muscle development: insights from chicken studies

Wen LUO, Bahareldin A. ABDALLA, Qinghua NIE, Xiquan ZHANG

Frontiers of Agricultural Science and Engineering 2017, Volume 4, Issue 3,   Pages 295-304 doi: 10.15302/J-FASE-2017159

Abstract: Skeletal muscle development is a complex multi-process trait regulated by various genetic factors.However, only a small proportion of the genetic factors affecting skeletal muscle development have beenThe aim of this review is to summarize recent knowledge about the genetic factors involved in the regulationof skeletal muscle development in the chicken, such as gene polymorphisms, epigenetic modification,

Keywords： chicken     epigenetic modification     miRNAs     skeletal muscle development     SNP     transcription factor    

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Natural killer cell lines in tumor immunotherapy

Min Cheng, Jian Zhang, Wen Jiang, Yongyan Chen, Zhigang Tian

Frontiers of Medicine 2012, Volume 6, Issue 1,   Pages 56-66 doi: 10.1007/s11684-012-0177-7

Abstract:

Natural killer (NK) cells are considered to be critical players in anticancer immunity. However, cancers are able to develop mechanisms to escape NK cell attack or to induce defective NK cells. Current NK cell-based cancer immunotherapy is aimed at overcoming NK cell paralysis through several potential approaches, including activating autologous NK cells, expanding allogeneic NK cells, usage of stable allogeneic NK cell lines and genetically modifying fresh NK cells or NK cell lines. The stable allogeneic NK cell line approach is more practical for quality-control and large-scale production. Additionally, genetically modifying NK cell lines by increasing their expression of cytokines and engineering chimeric tumor antigen receptors could improve their specificity and cytotoxicity. In this review, NK cells in tumor immunotherapy are discussed, and a list of therapeutic NK cell lines currently undergoing preclinical and clinical trials of several kinds of tumors are reviewed.

Keywords： natural killer cell     natural killer cell line     tumor immunotherapy     genetic modification    

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Challenges of NK cell-based immunotherapy in the new era

Fang Fang, Weihua Xiao, Zhigang Tian

Frontiers of Medicine 2018, Volume 12, Issue 4,   Pages 440-450 doi: tzg@ustc.edu.cn

Abstract:

Natural killer cells (NKs) have a great potential for cancer immunotherapy because they can rapidly and directly kill transformed cells in the absence of antigen presensitization. Various cellular sources, including peripheral blood mononuclear cells (PBMCs), stem cells, and NK cell lines, have been used for producing NK cells. In particular, NK cells that expanded from allogeneic PBMCs exhibit better efficacy than those that did not. However, considering the safety, activities, and reliability of the cell products, researchers must develop an optimal protocol for producing NK cells from PBMCs in the manufacture setting and clinical therapeutic regimen. In this review, the challenges on NK cell-based therapeutic approaches and clinical outcomes are discussed.

Keywords： natural killer cells     immunotherapy     adoptive transfer     genetic modification     immune checkpoint inhibitor    

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Sustainable functionalization and modification of materials via multicomponent reactions in water

Frontiers of Chemical Science and Engineering 2022, Volume 16, Issue 9,   Pages 1318-1344 doi: 10.1007/s11705-022-2150-6

Abstract: ground providing essential design criteria to develop advanced tools for efficient functionalization and modificationTo date, there is no exclusive review to report the sustainable functionalization and modification ofkinds of multicomponent reactions in water and aqueous media as green methods for functionalization and modification

Keywords： materials     multicomponent reactions     modification     functionalization     water    

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An investigation on modification mechanism of CH

Qiang XIN, Shanghong HUANG

Frontiers of Structural and Civil Engineering 2017, Volume 11, Issue 3,   Pages 293-300 doi: 10.1007/s11709-017-0403-0

Abstract: is used as cross linking agent, the concentrated sulfuric acid is used as catalyst, and the chemical modificationModification mechanism of low temperature coal is studied by Scanning Electron Microscopy and other analytical

Keywords： low temperature     coal tar pitch     modification     road performance    

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Research progress on low dielectric constant modification of cellulose insulating paper for power transformers

Frontiers of Chemical Science and Engineering 2023, Volume 17, Issue 8,   Pages 991-1009 doi: 10.1007/s11705-022-2259-7

Abstract: dielectric constant of a cellulose insulating paper can be effectively reduced by chemical or physical modificationThis study presents an overview of the foreign and domestic research status of the use of modification

Keywords： low dielectric constant     chemical and physical modification     cellulose insulating paper     transformer    

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Crystal modification of rifapentine using different solvents

Kun ZHOU, Jun LI, Jianhong LUO, Dongsheng ZHENG,

Frontiers of Chemical Science and Engineering 2010, Volume 4, Issue 1,   Pages 65-69 doi: 10.1007/s11705-009-0302-6

Abstract: investigation on those developed crystals clearly indicate that rifapentine has different crystal structure modificationwas obtained from acetic acid, the change of crystal habit was originated from the crystal structure modification

Keywords： identical     scanning calorimetry     different     comparative dissolution     structure modification    

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Surface modification techniques of membranes to improve their antifouling characteristics: recent advancements

Frontiers of Chemical Science and Engineering 2023, Volume 17, Issue 12,   Pages 1837-1865 doi: 10.1007/s11705-023-2347-3

Abstract: Surface modification techniques of membranes to improve their antifouling characteristics: recent advancements

Keywords： Surface modification techniques    

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Machine learning modeling identifies hypertrophic cardiomyopathy subtypes with genetic signature

Frontiers of Medicine 2023, Volume 17, Issue 4,   Pages 768-780 doi: 10.1007/s11684-023-0982-1

Abstract: By employing echocardiography and genetic screening for the 46 genes, HCM can be classified into two

Keywords： machine learning methods     hypertrophic cardiomyopathy     genetic risk    

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RNA m6A modification and its function in diseases

Jiyu Tong, Richard A. Flavell, Hua-Bing Li

Frontiers of Medicine 2018, Volume 12, Issue 4,   Pages 481-489 doi: 10.1007/s11684-018-0654-8

Abstract: p>N6-methyladenosine (m6A) is the most common post-transcriptional RNA modificationthroughout the transcriptome, affecting fundamental aspects of RNA metabolism. m6A modificationin m6A research and highlight the functional relevance and importance of m6A modification

Keywords： RNA modification     m6A     immunity     cancer     epigenetics    

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Hydrophilic modification of poly(aryl sulfone) membrane materials toward highly-efficient environmental

Frontiers of Chemical Science and Engineering 2022, Volume 16, Issue 5,   Pages 614-633 doi: 10.1007/s11705-021-2115-1

Abstract: give a comprehensive overview on characterizations of hydrophilic membrane and diverse hydrophilic modificationapproaches of poly(aryl sulfone) membranes, predominantly including bulky, blending and surface modificationThe discussions on the different modification methods have been provided in-depth.Besides, focusing on modification methods and performance of modified membranes, the related mechanisms

Keywords： poly(aryl sulfone)     membrane separations     modification     hydrophilicity     water treatment    

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Feasibility of bubble surface modification for natural organic matter removal from river water using

Yulong Shi, Jiaxuan Yang, Jun Ma, Congwei Luo

Frontiers of Environmental Science & Engineering 2017, Volume 11, Issue 6, doi: 10.1007/s11783-017-0954-2

Abstract: Positive bubble modification provides an alternative approach for DAF to enhance NOM removal.

Keywords： Bubble surface modification     Chitosan     Disinfection by-product     Dissolved air flotation     Organic fraction    

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Title Author Date Type Operation

Development of oncolytic virotherapy: from genetic modification to combination therapy

Qiaoshuai Lan, Shuai Xia, Qian Wang, Wei Xu, Haiyan Huang, Shibo Jiang, Lu Lu

Journal Article

Developments in genetic modification of cattle and implications for regulation, safety and traceability

Jan Pieter VAN DER BERG, Gijs A. KLETER, Evy BATTAGLIA, Martien A. M. GROENEN, Esther J. KOK

Journal Article

Plant genetic engineering and genetically modified crop breeding: history and current status

Xingchun WANG,Shujun CHANG,Jie LU,Rupert FRAY,Don GRIERSON,Yuanhuai HAN

Journal Article

The genetic regulation of skeletal muscle development: insights from chicken studies

Wen LUO, Bahareldin A. ABDALLA, Qinghua NIE, Xiquan ZHANG

Journal Article

Natural killer cell lines in tumor immunotherapy

Min Cheng, Jian Zhang, Wen Jiang, Yongyan Chen, Zhigang Tian

Journal Article

Challenges of NK cell-based immunotherapy in the new era

Fang Fang, Weihua Xiao, Zhigang Tian

Journal Article

Sustainable functionalization and modification of materials via multicomponent reactions in water

Journal Article

An investigation on modification mechanism of CH

Qiang XIN, Shanghong HUANG

Journal Article

Research progress on low dielectric constant modification of cellulose insulating paper for power transformers

Journal Article

Crystal modification of rifapentine using different solvents

Kun ZHOU, Jun LI, Jianhong LUO, Dongsheng ZHENG,

Journal Article

Surface modification techniques of membranes to improve their antifouling characteristics: recent advancements

Journal Article

Machine learning modeling identifies hypertrophic cardiomyopathy subtypes with genetic signature

Journal Article

RNA m6A modification and its function in diseases

Jiyu Tong, Richard A. Flavell, Hua-Bing Li

Journal Article

Hydrophilic modification of poly(aryl sulfone) membrane materials toward highly-efficient environmental

Journal Article

Feasibility of bubble surface modification for natural organic matter removal from river water using

Yulong Shi, Jiaxuan Yang, Jun Ma, Congwei Luo

Journal Article